Tuesday, October 03, 2006

Scientists find DNA mutation for white skin


Scientists Find DNA Change That Explains White Skin

By Rick Weiss
Washington Post Staff Writer
Friday, December 16, 2005; A01

Scientists said yesterday that they have discovered a tiny genetic
mutation that largely explains the first appearance of white skin in
humans tens of thousands of years ago, a finding that helps solve one
of biology's most enduring mysteries and illuminates one of humanity's
greatest sources of strife.

The work suggests that the skin-whitening mutation occurred by chance
in a single individual after the first human exodus from Africa, when
all people were brown-skinned. That person's offspring apparently
thrived as humans moved northward into what is now Europe, helping to
give rise to the lightest of the world's races.

Leaders of the study, at Penn State University, warned against
interpreting the finding as a discovery of "the race gene." Race is a
vaguely defined biological, social and political concept, they noted,
and skin color is only part of what race is -- and is not.

In fact, several scientists said, the new work shows just how small a
biological difference is reflected by skin color. The newly found
mutation involves a change of just one letter of DNA code out of the
3.1 billion letters in the human genome -- the complete instructions
for making a human being.

"It's a major finding in a very sensitive area," said Stephen
Oppenheimer, an expert in anthropological genetics at Oxford
University, who was not involved in the work. "Almost all the
differences used to differentiate populations from around the world
really are skin deep."

The work raises a raft of new questions -- not least of which is why
white skin caught on so thoroughly in northern climes once it arose.
Some scientists suggest that lighter skin offered a strong survival
advantage for people who migrated out of Africa by boosting their
levels of bone-strengthening vitamin D; others have posited that its
novelty and showiness simply made it more attractive to those seeking

The work also reveals for the first time that Asians owe their
relatively light skin to different mutations. That means that light
skin arose independently at least twice in human evolution, in each
case affecting populations with the facial and other traits that today
are commonly regarded as the hallmarks of Caucasian and Asian races.

Several sociologists and others said they feared that such revelations
might wrongly overshadow the prevailing finding of genetics over the
past 10 years: that the number of DNA differences between races is
tiny compared with the range of genetic diversity found within any
single racial group.

Even study leader Keith Cheng said he was at first uncomfortable
talking about the new work, fearing that the finding of such a clear
genetic difference between people of African and European ancestries
might reawaken discredited assertions of other purported inborn
differences between races -- the most long-standing and inflammatory
of those being intelligence.

"I think human beings are extremely insecure and look to visual cues
of sameness to feel better, and people will do bad things to people
who look different," Cheng said.

The discovery, described in today's issue of the journal Science, was
an unexpected outgrowth of studies Cheng and his colleagues were
conducting on inch-long zebra fish, which are popular research tools
for geneticists and developmental biologists. Having identified a gene
that, when mutated, interferes with its ability to make its
characteristic black stripes, the team scanned human DNA databases to
see if a similar gene resides in people.

To their surprise, they found virtually identical pigment-building
genes in humans, chickens, dogs, cows and many others species, an
indication of its biological value.

They got a bigger surprise when they looked in a new database
comparing the genomes of four of the world's major racial groups. That
showed that whites with northern and western European ancestry have a
mutated version of the gene.

Skin color is a reflection of the amount and distribution of the
pigment melanin, which in humans protects against damaging ultraviolet
rays but in other species is also used for camouflage or other
purposes. The mutation that deprives zebra fish of their stripes
blocks the creation of a protein whose job is to move charged atoms
across cell membranes, an obscure process that is crucial to the
accumulation of melanin inside cells.

Humans of European descent, Cheng's team found, bear a slightly
different mutation that hobbles the same protein with similar effect.
The defect does not affect melanin deposition in other parts of the
body, including the hair and eyes, whose tints are under the control
of other genes.

A few genes have previously been associated with human pigment
disorders -- most notably those that, when mutated, lead to albinism,
an extreme form of pigment loss. But the newly found glitch is the
first found to play a role in the formation of "normal" white skin.
The Penn State team calculates that the gene, known as slc24a5, is
responsible for about one-third of the pigment loss that made black
skin white. A few other as-yet-unidentified mutated genes apparently
account for the rest.

Although precise dating is impossible, several scientists speculated
on the basis of its spread and variation that the mutation arose
between 20,000 and 50,000 years ago. That would be consistent with
research showing that a wave of ancestral humans migrated northward
and eastward out of Africa about 50,000 years ago.

Unlike most mutations, this one quickly overwhelmed its ancestral
version, at least in Europe, suggesting it had a real benefit. Many
scientists suspect that benefit has to do with vitamin D, made in the
body with the help of sunlight and critical to proper bone

Sun intensity is great enough in equatorial regions that the vitamin
can still be made in dark-skinned people despite the ultraviolet
shielding effects of melanin. In the north, where sunlight is less
intense and cold weather demands that more clothing be worn, melanin's
ultraviolet shielding became a liability, the thinking goes.

Today that solar requirement is largely irrelevant because many foods
are supplemented with vitamin D.

Some scientists said they suspect that white skin's rapid rise to
genetic dominance may also be the product of "sexual selection," a
phenomenon of evolutionary biology in which almost any new and showy
trait in a healthy individual can become highly prized by those
seeking mates, perhaps because it provides evidence of genetic

Cheng and co-worker Victor A. Canfield said their discovery could have
practical spinoffs. A gene so crucial to the buildup of melanin in the
skin might be a good target for new drugs against melanoma, for
example, a cancer of melanin cells in which slc24a5 works overtime.

But they and others agreed that, for better or worse, the finding's
most immediate impact may be an escalating debate about the meaning of

Recent revelations that all people are more than 99.9 percent
genetically identical has proved that race has almost no biological
validity. Yet geneticists' claims that race is a phony construct have
not rung true to many nonscientists -- and understandably so, said
Vivian Ota Wang of the National Human Genome Research Institute in

"You may tell people that race isn't real and doesn't matter, but they
can't catch a cab," Ota Wang said. "So unless we take that into
account it makes us sound crazy."

(c) 2005 The Washington Post Company

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